Association between COX2 -765G/C polymorphism and periodontitis in Chinese population: a meta-analysis

BACKGROUND Studies had attempted to clarify the relation between COX2 -765G/C gene polymorphisms and periodontitis risk, but there has been no definite consensus to date. A meta-analysis was performed to further explore the relationship of COX2 -765G/C polymorphism on periodontitis risk among Chinese population. METHODS The databases of PubMed, Springer Link, Ovid, Chinese Wanfang Databases, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biology Medicine were searched up to January 2017. The overall result and subgroup analysis results were combined using fixed-effect or random-effect based on the heterogeneity. RESULTS Finally, 7 case-control publications including 1399 periodontitis cases and 1663 controls were identified according to the inclusion criteria. In the total analyses, COX2 -765G/C polymorphism had nonsignificant association on periodontitis risk in all models. The subgroup analyses suggested a significantly increased risk of periodontitis in studies with population-based controls and a significantly decreased risk in studies with hospital-based controls. CONCLUSIONS This meta-analysis indicated that COX2 -765G/C polymorphism had significantly affect on periodontitis risk among Chinese individuals, which should be confirmed by other ethnic groups.